The antiparkinsonian actions and pharmacokinetics of transdermal (+)-4-propyl-9-hydroxynaphthoxazine (+PHNO): preliminary results

URN to cite this document:: urn:nbn:de:bvb:355-epub-254491
DOI to cite this document:: 10.5283/epub.25449

Coleman, R. J. ; Lange, Klaus W. ; Quinn, N. P. ; Loper, A. E. ; Bondi, J. V. ; Hichens, M. ; Stahl, S. M. ; Marsden, C. D.

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Date of publication of this fulltext: 20 Jul 2012 13:25

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Abstract

(+)-4-Propyl-9-hydroxynaphthoxazine (+PHNO) is a potent dopamine agonist that has been administered transdermally to four patients with Parkinson's disease and "on-off" fluctuations. Skin patches of increasing size were used to treat these patients, who also received infrequent doses of oral levodopa if required. The effect of +PHNO was measured as an increased duration of action of individual ...