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Circling behavior in old rats after unilateral intranigral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Lange, Klaus W. (1989) Circling behavior in old rats after unilateral intranigral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life sciences 45 (18), pp. 1709-1714.

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Abstract

Old and young adult rats received unilateral injections of MPTP or saline into the substantia nigra. Unilateral injection of MPTP in old rats induced ipsiversive circling on day 1 and day 7 after the injection; contraversive circling behavior was induced in MPTP-treated rats by systemic administration of apomorphine. Young rats showed ipsiversive circling on day 1 but not on day 7 after the ...

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Item type:Article
Date:1989
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
2531261PubMed ID
Classification:
NotationType
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacologyMESH
Aging/metabolismMESH
AnimalsMESH
Behavior, Animal/drug effectsMESH
InjectionsMESH
MaleMESH
Neurotoxins/pharmacologyMESH
RatsMESH
Receptors, Dopamine/metabolismMESH
Receptors, Dopamine D2MESH
Substantia Nigra/metabolismMESH
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:25450
Owner only: item control page

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