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Unilateral intranigral injection of MPTP in the rat induces contraversive turning

Welzl, Hans and Lange, Klaus W. (1986) Unilateral intranigral injection of MPTP in the rat induces contraversive turning. European journal of pharmacology 132 (2-3), pp. 295-297.

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Abstract

Unilateral injection of MPTP into the pars compacta of the substantia nigra in rats induced contraversive turning immediately after the injection. Contraversive turning decreased, and reversed its direction after about 30 min. Ipsiversive turning was still present 24 h after the injection of MPTP. These results suggest that MPTP has an initial stimulatory effect on dopaminergic neurons followed by a depression of the activity of these cells.


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Item type:Article
Date:1986
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
3493164PubMed ID
Classification:
NotationType
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineMESH
AnimalsMESH
InjectionsMESH
MaleMESH
Pyridines/pharmacologyMESH
RatsMESH
Rats, Inbred StrainsMESH
Stereotyped Behavior/drug effectsMESH
Substantia NigraMESH
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:25453
Owner only: item control page

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