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Welzl, Hans ; Lange, Klaus W.

Unilateral intranigral injection of MPTP in the rat induces contraversive turning

Article

Welzl, Hans and Lange, Klaus W. (1986) Unilateral intranigral injection of MPTP in the rat induces contraversive turning. European journal of pharmacology 132 (2-3), pp. 295-297.

DOI to cite this document: 10.5283/epub.25453


Abstract

Unilateral injection of MPTP into the pars compacta of the substantia nigra in rats induced contraversive turning immediately after the injection. Contraversive turning decreased, and reversed its direction after about 30 min. Ipsiversive turning was still present 24 h after the injection of MPTP. These results suggest that MPTP has an initial stimulatory effect on dopaminergic neurons followed by a depression of the activity of these cells.



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Details

Item typeArticle
Journal or Publication TitleEuropean journal of pharmacology
PublisherElsevier
Volume132
Number of Issue or Book Chapter2-3
Page Rangepp. 295-297
Date1986
Date of publication20 Jul 2012 11:17
InstitutionsHuman Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number
ValueType
3493164PubMed ID
Classification
NotationType
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineMESH
AnimalsMESH
InjectionsMESH
MaleMESH
Pyridines/pharmacologyMESH
RatsMESH
Rats, Inbred StrainsMESH
Stereotyped Behavior/drug effectsMESH
Substantia NigraMESH
Dewey Decimal Classification100 Philosophy & psychology > 150 Psychology
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgUnknown
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-254539
Item ID25453

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