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Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets

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Löschmann, P. A. ; Smith, L. A. ; Lange, Klaus W. ; Jähnig, P. ; Jenner, P. ; Marsden, C. D.
Date of publication of this fulltext: 20 Jul 2012 10:09


The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets. Both the D-2 agonist quinpirole and the mixed D-1/D-2 agonist apomorphine reversed the motor impairments and induced locomotor activity. The D-1 antagonist SCH 23390 and the D-2 antagonist raclopride given alone further reduced motor function in ...


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