Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets

URN to cite this document:

urn:nbn:de:bvb:355-epub-254888 Copy

DOI to cite this document:

10.5283/epub.25488 Copy

Löschmann, P. A. ; Smith, L. A. ; Lange, Klaus W. ; Jähnig, P. ; Jenner, P. ; Marsden, C. D.

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Date of publication of this fulltext: 20 Jul 2012 10:09

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Details

Item type:	Article
Journal or Publication Title:	Psychopharmacology
Volume:	109
Number of Issue or Book Chapter:	1-2
Page Range:	pp. 49-56
Date:	1992
Institutions:	Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:	Value Type 1365671 PubMed ID
Classification:	Notation Type 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology MESH Animals MESH Behavior, Animal/drug effects MESH Callithrix MESH Dopamine Agents/pharmacology MESH Dopamine Agonists/pharmacology MESH Dopamine Antagonists/pharmacology MESH Dose-Response Relationship, Drug MESH Female MESH Male MESH Motor Activity/drug effects MESH Receptors, Dopamine D1/drug effects MESH Receptors, Dopamine D2/drug effects MESH
Dewey Decimal Classification:	100 Philosophy & psychology > 150 Psychology
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	25488

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Abstract

The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets. Both the D-2 agonist quinpirole and the mixed D-1/D-2 agonist apomorphine reversed the motor impairments and induced locomotor activity. The D-1 antagonist SCH 23390 and the D-2 antagonist raclopride given alone further reduced motor function in ...

Abstract

The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets. Both the D-2 agonist quinpirole and the mixed D-1/D-2 agonist apomorphine reversed the motor impairments and induced locomotor activity. The D-1 antagonist SCH 23390 and the D-2 antagonist raclopride given alone further reduced motor function in MPTP-treated animals. The actions of quinpirole were potently and completely inhibited by raclopride but only partially and inconsistently by SCH 23390. In contrast, the effects of apomorphine were markedly but incompletely inhibited by both raclopride and SCH 23390. The D-1 agonist SKF 38393 alone caused a dose related reduction in motor activity. SKF 38393 weakly and partially inhibited the improvements in motor function produced by quinpirole but had a more pronounced effect on apomorphine induced motor activity. The induction of motor activity in MPTP treated common marmosets may separately involve both D-1 and D-2 receptors. Comparison with our previous data on the effect of the same drugs in normal common marmosets provides some evidence for a breakdown of linkage between D-1 and D-2 systems following MPTP treatment. The actions of SKF 38393 in MPTP-treated common marmosets contrasts with its ability to induce behavioural activation and a facilitation of D-2 mediated behaviour in rodents. SKF 38393 may not be the compound with which to delineate the role of D-1 receptors in primates.

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Metadata last modified: 26 Nov 2020 04:20

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