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GLUTAMATERGIC MECHANISMS IN THE BRAIN IN MOVEMENT-DISORDERS AND SCHIZOPHRENIA

Lange, Klaus W. ; Kornhuber, J. ; Riederer, Peter


Abstract

Glutamate is the most important excitatory neurotransmitter in the mammalian brain. Recent findings suggest that dopamine is of less importance in the regulation of psychomotor functions than was previously believed. Central glutamatergic dysfunction appears to play a significant role in movement disorders and schizophrenia. An imbalance between dopaminergic and glutamatergic mechanisms is ...

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