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Regulation of T cell differentiation by the TGF-β inhibitor Smad7 and non-Smad pathways

URN to cite this document:
urn:nbn:de:bvb:355-epub-255445
Hasan, Md. Maruf
Date of publication of this fulltext: 04 Jul 2013 08:22


Abstract (English)

The cytokine transforming growth factor (TGF-β) has a pivotal role in T cell differentiation. Regulation of intracellular signalling pathways during T cell differentiation has been given a great attention recently. Under certain conditions TGF-β inhibits T helper (Th1) and Th2 differentiation or induces regulatory T cell and Th17 development, mainly through the Smad-dependent signalling pathway. ...

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Translation of the abstract (German)

Der Transformierende Wachstumsfaktor (Transforming Growth Factor β; TGF-β) spielt eine entscheidende Rolle in der T-Zelldifferenzierung. In letzter Zeit rückte die Regulation von intrazellulären Signalwegen während der T-Zelldifferenzierung vermehrt in den Fokus der Wissenschaft. Unter bestimmten Bedingungen inhibiert TGF-β die Differenzierung zu T-Helferzellen (Th) 1- und Th2-Zellen oder ...

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