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Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

Wege, Anja Kathrin, Florian, Christian, Ernst, Wolfgang, Zimara, Nicole, Schleicher, Ulrike, Hanses, Frank, Schmid, Maximilian and Ritter, Uwe (2012) Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response. PLoS Neglected Tropical Diseases 6, e1741.

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Date of publication of this fulltext: 07 Sep 2012 06:59

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Abstract

Background Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis. Unfortunately, chemotherapeutic interventions show high toxicity in addition to an increased risk of dissemination of drug-resistant parasites. An appropriate laboratory animal based model is still ...

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Item type:Article
Date:24 July 2012
Institutions:Medicine > Lehrstuhl für Immunologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pntd.0001741DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:25853
Owner only: item control page

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