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Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

URN to cite this document:
urn:nbn:de:bvb:355-epub-258537
DOI to cite this document:
10.5283/epub.25853
Wege, Anja Kathrin ; Florian, Christian ; Ernst, Wolfgang ; Zimara, Nicole ; Schleicher, Ulrike ; Hanses, Frank ; Schmid, Maximilian ; Ritter, Uwe
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License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 07 Sep 2012 06:59


Abstract

Background Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis. Unfortunately, chemotherapeutic interventions show high toxicity in addition to an increased risk of dissemination of drug-resistant parasites. An appropriate laboratory animal based model is still ...

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