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Modelling the Genetic Risk in Age-Related Macular Degeneration

URN to cite this document:
urn:nbn:de:bvb:355-epub-258626
Grassmann, Felix ; Fritsche, Lars G. ; Keilhauer, Claudia N. ; Heid, Iris M. ; Weber, Bernhard H. F.
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Date of publication of this fulltext: 07 Sep 2012 06:52


Abstract

Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, genetic variants from several gene loci have reproducibly been associated with this condition and likely explain a large proportion of disease. Here, we developed a genetic risk score (GRS) for AMD based on 13 risk ...

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