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Generation of myeloid-derived suppressor cells using prostaglandin E2

URN to cite this document:
Obermajer, Natasa ; Kalinski, Pawel
License: Creative Commons Attribution 3.0
PDF - Published Version
Date of publication of this fulltext: 23 Oct 2012 06:38


Myeloid-derived suppressor cells (MDSCs) are natural immunosuppressive cells and endogenous inhibitors of the immune system. We describe a simple and clinically-compatible method of generating large numbers of MDSCs, using the cultures of peripheral blood-isolated monocytes supplemented with prostaglandin E2 (PGE2). We observed that PGE2 induces endogenous COX2 expression in cultured monocytes, ...


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