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Regulation and function of Anoctamins, a new family of Ca2+ activated Cl- channels

URN to cite this document:
Tian, Yuemin
Date of publication of this fulltext: 22 Oct 2012 06:43

Abstract (English)

Anoctamins are a family of Ca2+ activated Cl- channels (CaCCs) that are ubiquitously expressed in almost every cell type in our body. Anoctamins play an essential role in volume regulation, epithelial Cl- secretion, neuronal excitability, and also nociception. Mutations in anoctamin proteins lead to various diseases including bone and muscle dystrophy, cerebellar ataxias, and blood coagulation ...


Translation of the abstract (German)

Anoctamine sind eine Familie von Ca2+ aktivierten Cl- Kanälen (CaCCs), die ubiquitär in den meisten Zellen des Körpers exprimiert werden. Anoctamine spielen eine essentielle Rolle für die Volumenregulation, epitheliale Sekretion, neuronale Erregbarkeit und auch für die Nozizeption. Mutationen der Anoctamin-Proteine führen zu verschiedenen Erkrankungen wie Knochen- und Muskeldystrophie, zerebrale ...


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