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Binding specificity of mouse ficolin to different bacterial strains

URN to cite this document:
urn:nbn:de:bvb:355-epub-265964
Muraveika, Liudmila
Date of publication of this fulltext: 27 Nov 2012 10:15


Abstract (English)

Ficolins belong to one of the trigger-proteins, which activate the lectin pathway of the complement cascade and form a class of pattern recognition receptors that bind specifically to carbohydrate moieties on microbial surfaces and provide the front line defense against infection. The goal of this work was to examine the potential of mouse ficolins A and B to adhere to various strains of ...

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Translation of the abstract (German)

Fikoline gehören zur Gruppe der Triggerproteine, die den Lektinweg des Komplementensystems aktivieren und eine Klasse der Rezeptoren darstellen, die spezifisch an Zuckermoleküle der mikrobiellen Oberflächen binden und dadurch zur Aktivierung des Immunsystems führen. Das Ziel dieser Arbeit ist das Bindungpotenzial der Mausfikoline A und B an unterschiedlichen Bakterien in Screeningsassays zu ...

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