Elektronenmikroskopische und inununhistochemische Untersuchungenzur augendrucksenkenden Wirkung von Prostaglandin F2alpha [Electron microscopy and immunohistochemical studies of the intraocular pressure lowering effect of prostaglandin F2 alpha]

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-268734 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.26873 Copy

Tamm, Ernst R. ; Rittig, M. ; Lütjen-Drecoll, E.

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Veröffentlichungsdatum dieses Volltextes: 04 Dez 2012 07:18

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Alternative Links zum Volltext:Pubmed

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Details

Dokumentenart:	Artikel
Titel eines Journals oder einer Zeitschrift:	Fortschritte der Ophthalmologie
Verlag:	Springer
Band:	87
Nummer des Zeitschriftenheftes oder des Kapitels:	6
Seitenbereich:	S. 623-629
Datum:	1990
Institutionen:	Biologie und Vorklinische Medizin > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Identifikationsnummer:	Wert Typ 2086407 PubMed-ID
Klassifikation:	Notation Art Animals MESH Ciliary Body/drug effects MESH Collagen/analysis MESH Dinoprost/pharmacology MESH Immunohistochemistry MESH Intraocular Pressure/drug effects MESH Laminin/analysis MESH Macaca fascicularis MESH Microscopy, Electron MESH
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Unbekannt / Keine Angabe
Dokumenten-ID:	26873

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Zusammenfassung

Topically applied prostaglandin F2 alpha (PGF2 alpha) has been shown to lower intraocular pressure in cynomolgus monkeys. In this study the morphological changes following topical treatment of seven cynomolgus monkeys with 4 micrograms PGF2 alpha isopropylester for 5-8 days were investigated and compared with the eyes of five normal animals. Quantitative light microscopical, ultrastructural and ...

Zusammenfassung

Topically applied prostaglandin F2 alpha (PGF2 alpha) has been shown to lower intraocular pressure in cynomolgus monkeys. In this study the morphological changes following topical treatment of seven cynomolgus monkeys with 4 micrograms PGF2 alpha isopropylester for 5-8 days were investigated and compared with the eyes of five normal animals. Quantitative light microscopical, ultrastructural and immunhistochemical methods were used. No cellular signs of inflammation were seen in any of the eyes. Slight edema in the most anterior part of the ciliary processes occurred in most eyes, but only in parts of the circumference. The most pronounced change was dilation of the intramuscular spaces within the ciliary muscle. No changes were observed in the extracellular matrix within the muscle bundles, which consist partly of type IV and VI collagen, laminin and fibronectin. In the connective tissue between the muscle bundles, loss of collagen type I and III fibrils was observed. Additionally, macrophages were found with phagolysosomes containing phagocytized collagen fibrils. We suggest that loss of extracellular material leads to a widening of the uveoscleral outflow pathways of ciliary muscle and thereby to a reduction in intraocular pressure.

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