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Entwicklung von Enzymdesignalgorithmen mit flexibler Ligandenpositionierung

Birzer, Dietmar (2013) Entwicklung von Enzymdesignalgorithmen mit flexibler Ligandenpositionierung. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Dec 2013 15:35

Abstract (German)

Enzyme sind hocheffziente Biokatalysatoren, die ein breites Spektrum chemischer Reaktionen katalysieren. Diese Effzienz und die Tatsache dass Substrate in der Regel hochspezifisch umgesetzt werden, prädestiniert deren Einsatz in vielen Bereichen der Medizin und der Biotechnologie. Allerdings erfüllt nur ein kleiner Teil der wildtypischen Enzyme die speziellen Anforderungen industrieller Verfahren. ...

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Translation of the abstract (English)

A broad range of chemical reactions is catalyzed by enzymes, which are usually highly efficient and additionally show remarkably high substrate specificity. However, if it comes to their utilization in industrial processes, only few naturally evolved enzymes fulfill all requirements imposed by technical applications. Hence, there is a great demand for methods that allow for the design of ...

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Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:2 December 2013
Referee:apl. Prof. Dr Rainer Merkl
Date of exam:28 November 2012
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Keywords:Computergestütztes Enzymdesign, Ligandenpositionierung, Proteindesign, Ligandenbindung, PRA-Isomerase, Rosetta, Propka, DSX, computational biology, protein design, computational enzyme design, ligand binding, active sites, ligand positioning
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:26898
Owner only: item control page

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