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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-269361
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.26936
Alternative Links zum Volltext:Pubmed
Zusammenfassung
Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation. When isolated hepatocytes were incubated at reduced oxygen tensions for 18-48 h, we found increased secretion of EPO protein and elevated levels of EPO mRNA, ...
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