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Disparate effects of calcium channel blockers on pressure dependence of renin secretion and flow in the isolated perfused rat kidney

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Scholz, Holger ; Kurtz, Armin
Date of publication of this fulltext: 06 Dec 2012 13:50


Using the model of isolated perfused rat kidneys this study was performed to investigate whether or not voltage-operated calcium channels are essentially involved in the pressure control of renin secretion from the kidneys. At a perfusion pressure of 100 mm Hg (13.3 kPa) renin secretory rates were 4.2 +/- 0.7 (ng angiotensin I h-1) min-1 g-1. Stepwise reduction of renal perfusion pressure to 80, ...


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