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Amiloride enhances the secretion but not the synthesis of renin in renal juxtaglomerular cells

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Kurtz, Armin ; Della Bruna, R. ; Scholz, Holger ; Baier, Wolfgang
Date of publication of this fulltext: 06 Dec 2012 13:49


In this study we have examined a potential role of the sodium/proton exchange system in the regulation of renin secretion. We found that the inhibitors of the Na+/H+ antiport, amiloride (1 mM) and ethylisopropylamiloride (EIPA, 50 microM), led to a 125% increase of renin secretion from cultured mouse juxtaglomerular cells. The stimulatory effect of EIPA on renin secretion was dependent on the ...


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