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Oxygen-dependent erythropoietin production by the isolated perfused rat kidney

URN to cite this document:
urn:nbn:de:bvb:355-epub-269622
Scholz, Holger ; Schurek, H. J. ; Eckardt, Kai-Uwe ; Kurtz, Armin ; Bauer, Christian
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Date of publication of this fulltext: 06 Dec 2012 13:48


Abstract

In this study we have investigated the role of oxygen delivery and of classic second messengers on erythropoietin production by the isolated perfused rat kidney. We found that the rat kidney was capable of de novo synthesis of erythropoietin. The erythropoietin production rate was inversely related to the oxygen pressure in the perfusate and increased from 0.17 to 1.85 U erythropoietin h-1 g ...

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