Rat juxtaglomerular cells are endowed with DA-1 dopamine receptors mediating renin release

URN to cite this document:: urn:nbn:de:bvb:355-epub-269920
DOI to cite this document:: 10.5283/epub.26992

Kurtz, Armin ; Della Bruna, R. ; Pratz, J. ; Cavero, I.

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Date of publication of this fulltext: 20 Dec 2012 14:33

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Abstract

Under control conditions a primary culture containing about 80-90% of granular juxtaglomerular (JG) cells prepared from rat kidneys continuously released renin into the culture medium at a rate of 17.9 +/- 1.4 ng angiotensin I/h per mg of cell proteins per 30 min (n = 14). Dopamine (1.0 microM), the DA-1 dopamine receptor agonist fenoldopam (0.5 microM), and isoproterenol (1.0 microM) increased ...