Role of prostaglandins in hypoxia-stimulated erythropoietin production

URN to cite this document:: urn:nbn:de:bvb:355-epub-270147
DOI to cite this document:: 10.5283/epub.27014

Kurtz, Armin ; Jelkmann, W. ; Pfeilschifter, J. ; Bauer, Christian

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Date of publication of this fulltext: 05 Dec 2012 10:27

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Abstract

The role of prostaglandins in the mediation of hypoxia-stimulated erythropoietin (Ep) production by cultured rat renal mesangial cells was examined. It was found that an increase in prostaglandin E2 (PGE2) production accompanied the rise in Ep due to hypoxia (2% O2). The hypoxia-stimulated increase in Ep production was abolished in the presence of the cyclooxygenase inhibitor indomethacin (10(-5) ...