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Role of prostaglandins in hypoxia-stimulated erythropoietin production

Kurtz, Armin, Jelkmann, W., Pfeilschifter, J. and Bauer, Christian (1985) Role of prostaglandins in hypoxia-stimulated erythropoietin production. The American journal of physiology. Cell physiology 249 (1 Pt 1), C3-C8.

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Abstract

The role of prostaglandins in the mediation of hypoxia-stimulated erythropoietin (Ep) production by cultured rat renal mesangial cells was examined. It was found that an increase in prostaglandin E2 (PGE2) production accompanied the rise in Ep due to hypoxia (2% O2). The hypoxia-stimulated increase in Ep production was abolished in the presence of the cyclooxygenase inhibitor indomethacin (10(-5) ...

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Item type:Article
Date:1985
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
2990227PubMed ID
Classification:
NotationType
Adenylate Cyclase/metabolismMESH
AnimalsMESH
Arachidonic AcidMESH
Arachidonic Acids/pharmacologyMESH
Cells, CulturedMESH
Cyclic AMP/biosynthesisMESH
Cyclooxygenase InhibitorsMESH
DinoprostoneMESH
Diterpenes/pharmacologyMESH
Enzyme Activation/drug effectsMESH
Erythropoietin/biosynthesisMESH
ForskolinMESH
Glomerular Mesangium/metabolismMESH
Indomethacin/pharmacologyMESH
MaleMESH
Oxygen/physiologyMESH
Prostaglandins/physiologyMESH
Prostaglandins E/biosynthesisMESH
RatsMESH
Rats, Inbred StrainsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:27014
Owner only: item control page

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