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Small molecules as inhibitors of streptococcal hyaluronidase: a computer-assisted and multicomponent synthesis approach

URN to cite this document:
Textor, Christian
Date of publication of this fulltext: 03 Sep 2013 13:23

Abstract (English)

Hyaluronidases are enzymes that degrade hyaluronan, a major constituent of the extracellular matrix. As the role of hyaluronidases is far from being understood, potent and selective inhibitors are required as pharmacological tools. Moreover, inhibitors of the bacterial and mammalian enzymes might be useful agents in the treatment of various diseases, e.g. bacterial infections. Previously, we ...


Translation of the abstract (German)

Hyaluronidasen sind Enzyme, die Hyaluronsäure, einen wesentlichen Bestandteil der extrazellulären Matrix, abbauen. Da die (patho)physiologische Rolle der Hyaluronidasen weitgehend unverstanden ist, werden potente und selektive Inhibitoren als pharmakologische Werkzeuge benötigt. Zudem könnten Inhibitoren von bakteriellen und humanen Enzymen nützliche Wirkstoffe bei der Behandlung von ...


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