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Generation of a neonatal sepsis model in humanized mice

Ernst, Wolfgang (2012) Generation of a neonatal sepsis model in humanized mice. PhD, Universität Regensburg.

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Date of publication of this fulltext: 21 Dec 2012 07:34

Abstract (English)

Streptococcus agalactiae (group B streptococcus (GBS)) is a gram-positive bacterium and a harmless commensal in the gastrointestinal and vaginal flora of healthy adults. In neonates however, GBS is a leading cause for pneumonia, respiratory failure, bacteremia, sepsis and meningitis. In this study, a new animal model for GBS-induced sepsis is introduced, a mouse featuring a human immune system ...

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Translation of the abstract (German)

Streptococcus agalactiae (Streptokokkus der Serogruppe B (GBS)) ist ein grampositives Bakterium und in gesunden Erwachsenen als harmloser Kommensale in der gastrointestinalen und vaginalen Flora zu finden. In Neonaten jedoch ist dieser Keim einer der Hauptverursacher von Pneumonie, Atemversagen, Bakteriämie, Sepsis und Meningitis. Im Rahmen dieser Dissertation konnte ein neues Tiermodell für ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:22 December 2012
Referee:Prof. Dr. Daniela N. Männel
Date of exam:5 December 2012
Institutions:Medicine > Lehrstuhl für Immunologie
Keywords:sepsis, humanized mice, neonatal, group B streptococcus
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:27174
Owner only: item control page

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