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Inhibition of leukotriene receptors boosts neural progenitor proliferation

Huber, Christophe (2013) Inhibition of leukotriene receptors boosts neural progenitor proliferation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 20 Feb 2013 11:34

Abstract (English)

Neural stem and progenitor cells serve as a reservoir for new neurons in the adult brain throughout lifetime. One of the critical steps determining the net production of new neurons is neural progenitor proliferation, which needs to be tightly controlled. Since inflammation has detrimental effects on neurogenesis and the 5-lipoxygenase/leukotriene pathway is involved in inflammatory processes, we ...

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Translation of the abstract (German)

Neuronale Stamm- und Vorläuferzellen im adulten Gehirn dienen während des gesamten Lebens als Reservoir für neue Neurone. Einer der kritischen Schritte, welcher die Produktion neuer Neurone bestimmt und dabei streng kontrolliert werden muss, ist die Proliferation der neuronalen Progenitoren. Weil Entzündungsreaktionen einen hemmenden Effekt auf die Neurogenese haben und der ...

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Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:20 February 2013
Referee:Prof. Dr. Ludwig Aigner
Date of exam:15 February 2013
Institutions:Medicine > Lehrstuhl für Neurologie
Keywords:Neurogenese, Neurogenesis, progenitor, stem cell, Neuronale Vorläufer, Stammzellen, NSC, NPC, Proliferation, differentiation, Differenzierung, Montelukast, Leukotrien, GPR17, CysLT1, CysLT2, ERK, MAP-Kinase, 5-Lipoxygenase, 5-LOX
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:27727
Owner only: item control page

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