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The role of the proteoglycan versican in high-grade gliomas

Onken, Julia Sophie (2013) The role of the proteoglycan versican in high-grade gliomas. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Mar 2013 11:49

Abstract (German)

Die Dissertationsschrift beschäftigt sich mit dem Einfluss eines Extrazellulär-Matrix- Proteins Versican und seine Splice-Varianten (V0, V1, V2 und V3) auf das Verhalten von humanen Glioblastomzellen in vitro. Bei einem Glioblastom (Glioblastoma multiforme) handelt es sich um einen Tumor glialen Ursprungs im zentralen Nervensystems. Gliome können anhand ihrer Malignitätskriterien und ...

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Translation of the abstract (English)

This thesis was able to show that siV1, but not siV3, significantly
decreases the migration of glioma cells lines. This inhibition of
migration is not attributable to the increased attachment of cells, one
of the steps in tumour cell invasion. In addition, siV1 decreased
proliferation in glioma cell lines. I therefore postulate that the
versican isoform V1, but not V2 or V3, is an essential modulator of
glioma cell migration and proliferation.


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Item type:Thesis of the University of Regensburg (PhD)
Date:18 March 2013
Referee:Prof. Dr. Peter Hau
Date of exam:8 February 2013
Institutions:Medicine > Lehrstuhl für Neurologie
Keywords:Versican, Proteoglycan, Extrazelluläre Matrix, Gliom
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:27863
Owner only: item control page

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