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Intrazellulärer Transport von Zilium-assoziierten Proteinen

URN to cite this document:
urn:nbn:de:bvb:355-epub-283783
Gürster, Sonja
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Date of publication of this fulltext: 18 Jun 2013 11:15


Abstract (German)

Anhand von transmissionselektronenmikroskopischen Untersuchungen an renalen Tubulus-Epithelzellen sollten weitere Einblicke in die autosomal-polyzystische Nierenerkrankung (ADPKD) gewonnen werden. Dieser Krankheit liegt eine Fehlfunktion eines antennenartigen Zellorganells, des primären Ziliums, zugrunde, welches u. a. durch Mutationen des integralen Membranproteins Polycystin-2 (PC2) verursacht ...

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Translation of the abstract (English)

Transmission electron microscopy studies of renal epithelial cells should provide further insights into autosomal polycystic kidney disease (ADPKD). This disease is based on a malfunction of an antenna-like cellular organelle, the primary cilium, caused by mutations of the integral membrane protein Polycystin-2 (PC2). This protein is localized in the cytoplasm as well as in the cilium, which was ...

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