Go to content
UR Home

Analyse der neuroprotektiven und angiogenen Eigenschaften von Norrin in der Netzhaut

Zeilbeck, Ludwig Franz (2013) Analyse der neuroprotektiven und angiogenen Eigenschaften von Norrin in der Netzhaut. PhD, Universität Regensburg.

[img]
Preview
License: Publishing license for publications including print on demand
PDF
Download (8MB)
Date of publication of this fulltext: 01 Aug 2013 11:05

Abstract (German)

Norrin ist ein sekretiertes Signalprotein, das in der Retina über neuroprotektives und angiogenes Potential verfügt. So schützt die intravitreale Injektion von rhNorrin vor der NMDA-vermittelten exzitotoxischen Schädigung retinaler Ganglienzellen (RGC) und die ektope Norrin-Überexpression in βB1-Norrin Mäusen fördert die Rekapillarisierung vasoobliterierter Areale nach einer ...

plus

Translation of the abstract (English)

Norrin is a secreted signaling protein, which has neuroprotective and angiogenic properties in the retina. Intravitreal injection of rhNorrin protects against NMDA-induced excitotoxic damage of retinal ganglion cells (RGC). Moreover, ectopic overexpression of Norrin promotes capillary regrowth into vaso-obliterated areas of βB1-Norrin mice following oxygen-induced retinopathy (OIR). Studies in ...

plus


Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:1 August 2013
Referee:PD Dr. Andreas Ohlmann
Date of exam:25 July 2013
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie
Interdisciplinary Subject Network:Not selected
Research groups and research centres:Not selected
Keywords:Norrin, Neuroprotektion, DBA/2J, Glaukom, Lithium, kanonischer Wnt-Signalweg, ROP, IGF-1, Angiogenese, β-Catenin
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28627
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons