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Large-scale organization of ribosomal DNA chromatin is regulated by Tip5

Zillner, Karina, Filarsky, Michael, Rachow, Katrin, Weinberger, Michael, Längst, Gernot and Németh, Attila (2013) Large-scale organization of ribosomal DNA chromatin is regulated by Tip5. Nucleic Acids Research 41 (10), pp. 5251-5262.

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Date of publication of this fulltext: 05 Sep 2013 12:35

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Abstract

The DNase I accessibility and chromatin organization of genes within the nucleus do correlate to their transcriptional activity. Here, we show that both serum starvation and overexpression of Tip5, a key regulator of ribosomal RNA gene (rDNA) repression, dictate DNase I accessibility, facilitate the association of rDNA with the nuclear matrix and thus regulate large-scale rDNA chromatin ...

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Item type:Article
Date:2013
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
23580549PubMed ID
10.1093/nar/gkt218DOI
Classification:
NotationType
Biological TransportMESH
Cell LineMESH
Cell Nucleolus/ultrastructureMESH
Chromatin/chemistryMESH
Chromosomal Proteins, Non-Histone/metabolismMESH
DNA, Ribosomal/metabolismMESH
HumansMESH
Matrix Attachment RegionsMESH
Nuclear Matrix/metabolismMESH
Protein Structure, TertiaryMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28804
Owner only: item control page

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