Large-scale organization of ribosomal DNA chromatin is regulated by Tip5

URN to cite this document:: urn:nbn:de:bvb:355-epub-288043
DOI to cite this document:: 10.5283/epub.28804

Zillner, Karina ; Filarsky, Michael ; Rachow, Katrin ; Weinberger, Michael ; Längst, Gernot ; Németh, Attila

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Date of publication of this fulltext: 05 Sep 2013 12:35

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Abstract

The DNase I accessibility and chromatin organization of genes within the nucleus do correlate to their transcriptional activity. Here, we show that both serum starvation and overexpression of Tip5, a key regulator of ribosomal RNA gene (rDNA) repression, dictate DNase I accessibility, facilitate the association of rDNA with the nuclear matrix and thus regulate large-scale rDNA chromatin ...