NMR spectroscopy of macrophages loaded with native, oxidized or enzymatically degraded lipoproteins

URN to cite this document:: urn:nbn:de:bvb:355-epub-288156

Ramm Sander, Paul ; Peer, Markus ; Grandl, Margot ; Bogdahn, Ulrich ; Schmitz, Gerd ; Kalbitzer, Hans Robert

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Date of publication of this fulltext: 09 Sep 2013 11:39

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Abstract

Oxidized and enzymatically modified low-density lipoproteins (oxLDL and eLDL) play a key role in early stages of atherogenesis. Their uptake by recruited macrophages leads to endolysosomal phospholipidosis or foam cell formation, respectively, each of which is preceded by highly differential lipid restructuring processes. We applied (1)H-NMR spectroscopy (NMRS) to elucidate these structural ...