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NMR spectroscopy of macrophages loaded with native, oxidized or enzymatically degraded lipoproteins

Ramm Sander, Paul, Peer, Markus, Grandl, Margot, Bogdahn, Ulrich, Schmitz, Gerd and Kalbitzer, Hans Robert (2013) NMR spectroscopy of macrophages loaded with native, oxidized or enzymatically degraded lipoproteins. PloS one 8 (2), e56360.

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Date of publication of this fulltext: 09 Sep 2013 11:39

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Abstract

Oxidized and enzymatically modified low-density lipoproteins (oxLDL and eLDL) play a key role in early stages of atherogenesis. Their uptake by recruited macrophages leads to endolysosomal phospholipidosis or foam cell formation, respectively, each of which is preceded by highly differential lipid restructuring processes. We applied (1)H-NMR spectroscopy (NMRS) to elucidate these structural ...

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Item type:Article
Date:2013
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
9514405PubMed ID
10.1371/journal.pone.0056360DOI
Classification:
NotationType
HumansMESH
Hydrophobic and Hydrophilic InteractionsMESH
Lipoproteins, LDL/metabolismMESH
Macrophages/metabolismMESH
Nuclear Magnetic Resonance, BiomolecularMESH
Oxidation-ReductionMESH
ProteolysisMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28815
Owner only: item control page

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