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Sontag, Thomas-Alexander ; Fuermaier, Anselm B. M. ; Hauser, Joachim ; Kaunzinger, Ivo ; Tucha, Oliver ; Lange, Klaus W.

Spatial Memory in Spontaneously Hypertensive Rats (SHR)

Sontag, Thomas-Alexander, Fuermaier, Anselm B. M., Hauser, Joachim, Kaunzinger, Ivo, Tucha, Oliver und Lange, Klaus W. (2013) Spatial Memory in Spontaneously Hypertensive Rats (SHR). PloS one 8 (8), e74660.

Veröffentlichungsdatum dieses Volltextes: 12 Sep 2013 11:49
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.28838


Zusammenfassung

The spontaneously hypertensive rat (SHR) is an established animal model of ADHD. It has been suggested that ADHD symptoms arise from deficits in executive functions such as working memory, attentional control and decision making. Both ADHD patients and SHRs show deficits in spatial working memory. However, the data on spatial working memory deficits in SHRs are not consistent. It has been ...

The spontaneously hypertensive rat (SHR) is an established animal model of ADHD. It has been suggested that ADHD symptoms arise from deficits in executive functions such as working memory, attentional control and decision making. Both ADHD patients and SHRs show deficits in spatial working memory. However, the data on spatial working memory deficits in SHRs are not consistent. It has been suggested that the reported cognitive deficits of SHRs may be related to the SHRs' locomotor activity. We have used a holeboard (COGITAT) to study both cognition and activity in order to evaluate the influence of the activity on the cognitive performance of SHRs. In comparison to Wistar-Kyoto (WKY) rats, SHRs did not have any impairment in spatial working memory and reference memory. When the rats' locomotor activity was taken into account, the SHRs' working memory and reference memory were significantly better than in WKY rats. The locomotor activity appears to be a confounding factor in spatial memory tasks and should therefore be controlled for in future studies. In the SHR model of ADHD, we were unable to demonstrate an impairment of working memory which has been reported in patients with ADHD.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftPloS one
Verlag:PUBLIC LIBRARY SCIENCE
Ort der Veröffentlichung:SAN FRANCISCO
Band:8
Nummer des Zeitschriftenheftes oder des Kapitels:8
Seitenbereich:e74660
Datum2013
InstitutionenHumanwissenschaften > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identifikationsnummer
WertTyp
24009775PubMed-ID
10.1371/journal.pone.0074660DOI
Stichwörter / KeywordsATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; DEFICIT HYPERACTIVITY DISORDER; CENTRAL NICOTINIC RECEPTORS; ANIMAL-MODEL; COGNITIVE IMPAIRMENT; WORKING-MEMORY; WISTAR-KYOTO; PERFORMANCE; AMPHETAMINE; DOPAMINE;
Dewey-Dezimal-Klassifikation100 Philosophie und Psychologie > 150 Psychologie
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-288388
Dokumenten-ID28838

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