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Characterization of the retinal degeneration and glial activation of neuronal ceroid lipofuscinosis mouse models Cln3Δex7-8 and Cln6nclf and the beneficial effects of dietary supplementation

URN to cite this document:
urn:nbn:de:bvb:355-epub-288922
Mirza, Myriam
Date of publication of this fulltext: 16 Oct 2013 15:15


Abstract (English)

Microglia are specialized macrophages of the central nervous system involved in immune regulation, tissue development, homeostasis and wound repair. In healthy tissue, microglia are found in a ramified state which is tightly controlled by neurons. Upon insult, microglia undergo morphological changes, resembling active phagocytic macrophages and are highly motile. In neurodegenerative diseases, ...

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Translation of the abstract (German)

Mikrogliazellen sind spezialisierte Makrophagen des zentralen Nervensystems, die an der Immunoregulation, Gewebeentwicklung und Wungheilung beteiligt sind. Im gesunden Gewebe liegen Mikrogliazellen in einer verzweigten Form vor, welche von Neuronen kontrolliert wird. Nach einer Schädigung ändert sich die Morphologie der Mikrogliazellen und ähnelt dann der von aktivierten, phagozytischen ...

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