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Characterization of the retinal degeneration and glial activation of neuronal ceroid lipofuscinosis mouse models Cln3Δex7-8 and Cln6nclf and the beneficial effects of dietary supplementation

Mirza, Myriam (2013) Characterization of the retinal degeneration and glial activation of neuronal ceroid lipofuscinosis mouse models Cln3Δex7-8 and Cln6nclf and the beneficial effects of dietary supplementation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Oct 2013 15:15

Abstract (English)

Microglia are specialized macrophages of the central nervous system involved in immune regulation, tissue development, homeostasis and wound repair. In healthy tissue, microglia are found in a ramified state which is tightly controlled by neurons. Upon insult, microglia undergo morphological changes, resembling active phagocytic macrophages and are highly motile. In neurodegenerative diseases, ...

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Translation of the abstract (German)

Mikrogliazellen sind spezialisierte Makrophagen des zentralen Nervensystems, die an der Immunoregulation, Gewebeentwicklung und Wungheilung beteiligt sind. Im gesunden Gewebe liegen Mikrogliazellen in einer verzweigten Form vor, welche von Neuronen kontrolliert wird. Nach einer Schädigung ändert sich die Morphologie der Mikrogliazellen und ähnelt dann der von aktivierten, phagozytischen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:16 October 2013
Referee:Prof. Dr. Thomas Langmann
Date of exam:30 September 2013
Institutions:Medicine > Lehrstuhl für Humangenetik
Keywords:Neuronal ceroid lipofucsinosis, retinal degeneration, microglia
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28892
Owner only: item control page

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