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The role of BMP and TGFß signalling in the terminal differentiation in the in vitro chondrogenesis of mesenchymal stem cells

Karl, Alexandra (2013) The role of BMP and TGFß signalling in the terminal differentiation in the in vitro chondrogenesis of mesenchymal stem cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Oct 2013 11:55

Abstract (English)

Articular cartilage has a poor intrinsic repair capacity after injury and cartilage lesions may lead to further degeneration and osteoarthritis. Mesenchymal stem cells (MSCs) are a promising cell source for tissue engineering approaches to repair articular cartilage lesions. During in vitro chondrogenesis, MSCs express articular cartilage markers like collagen II and aggrecan. However, ...

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Translation of the abstract (German)

Artikulärer Knorpel weist eine schlechte Regenerationsfähigkeit nach Verletzungen auf und Knorpelverletzungen können zu weiteren Degenerationen und Osteoarthritis führen. Mesenchymale Stammzellen (MSCs) sind eine vielversprechende Zellquelle für die Entwicklung von Tissue Engineering Produkten zur Reparatur von lokalisierten Knorpelschäden. In den üblicherweise verwendeten in vitro Chondrogenese ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:18 October 2013
Referee:Prof. Dr. Peter Angele
Date of exam:15 October 2013
Institutions:Medicine > Lehrstuhl für Unfallchirurgie
Keywords:Mesenchymal stem cells, Chondrogenesis, tissue engineering, cartilage
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:28940
Owner only: item control page

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