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The role of BMP and TGFß signalling in the terminal differentiation in the in vitro chondrogenesis of mesenchymal stem cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-289408
Karl, Alexandra
Date of publication of this fulltext: 18 Oct 2013 11:55


Abstract (English)

Articular cartilage has a poor intrinsic repair capacity after injury and cartilage lesions may lead to further degeneration and osteoarthritis. Mesenchymal stem cells (MSCs) are a promising cell source for tissue engineering approaches to repair articular cartilage lesions. During in vitro chondrogenesis, MSCs express articular cartilage markers like collagen II and aggrecan. However, ...

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Translation of the abstract (German)

Artikulärer Knorpel weist eine schlechte Regenerationsfähigkeit nach Verletzungen auf und Knorpelverletzungen können zu weiteren Degenerationen und Osteoarthritis führen. Mesenchymale Stammzellen (MSCs) sind eine vielversprechende Zellquelle für die Entwicklung von Tissue Engineering Produkten zur Reparatur von lokalisierten Knorpelschäden. In den üblicherweise verwendeten in vitro Chondrogenese ...

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