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Synthesis and dual histamine H1 and H2 receptor antagonist activity of cyanoguanidine derivatives

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Sadek, Bassem ; Alisch, Rudi ; Buschauer, Armin ; Elz, Sigurd
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Date of publication of this fulltext: 12 Nov 2013 08:33


Premedication with a combination of histamine H1 receptor (H1R) and H2 receptor (H2R) antagonists has been suggested as a prophylactic principle in anesthesia and surgery. Aiming at pharmacological hybrids combining H1R and H2R antagonistic activity, a series of cyanoguanidines (14-35) was synthesized by linking mepyramine-type H1R antagonist substructures with roxatidine-, tiotidine-, or ...


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