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Synthesis and dual histamine H1 and H2 receptor antagonist activity of cyanoguanidine derivatives

Sadek, Bassem, Alisch, Rudi, Buschauer, Armin and Elz, Sigurd (2013) Synthesis and dual histamine H1 and H2 receptor antagonist activity of cyanoguanidine derivatives. Molecules 18 (11), pp. 14186-14202.

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Date of publication of this fulltext: 12 Nov 2013 08:33

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Abstract

Premedication with a combination of histamine H1 receptor (H1R) and H2 receptor (H2R) antagonists has been suggested as a prophylactic principle in anesthesia and surgery. Aiming at pharmacological hybrids combining H1R and H2R antagonistic activity, a series of cyanoguanidines (14-35) was synthesized by linking mepyramine-type H1R antagonist substructures with roxatidine-, tiotidine-, or ...

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Item type:Article
Date:15 November 2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
10.3390/molecules181114186DOI
Related URLs:
URLURL Type
http://www.mdpi.com/1420-3049/18/11/14186Publisher
Keywords:dual H1/H2 receptor antagonists; mepyramine; roxatidine; tiotidine; ranitidine
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:28983
Owner only: item control page

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