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Comparative studies on elongation and termination of the three RNA polymerases from S. cerevisiae in vitro

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Merkl, Philipp
Date of publication of this fulltext: 12 Nov 2014 13:30

Abstract (English)

In Saccharomyces cerevisiae (hereafter called yeast), three RNA polymerases synthesize the nuclear transcriptome. During the transcriptional cycle, RNA polymerase I, II and III (Pol I, II and III) are recruited to their respective promoter, elongate the nascent transcript in the context of chromatin and finally terminate transcription. Whereas the initation step is quite well understood, our ...


Translation of the abstract (German)

In S. cerevisiae synthetisieren drei RNA Polymerasen das Transkriptom des Nukleus. Während eines Transkriptionszyklus werden die RNA Polymerasen I, II und III (Pol I, II und III) an ihren jeweiligen Promotor rekrutiert, synthetisieren die entstehende RNA und terminieren die Transkription schlussendlich. Der Prozess der Initiation ist bereits ausführlich beschrieben, wohingegen unser Wissen über ...


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