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How Subvisible Particles Become Invisible - Relevance of the Refractive Index for Protein Particle Analysis

Zölls, Sarah, Gregoritza, Manuel, Tantipolphan, Ruedeeporn, Wiggenhorn, Michael, Winter, Gerhard, Friess, Wolfgang and Hawe, Andrea (2013) How Subvisible Particles Become Invisible - Relevance of the Refractive Index for Protein Particle Analysis. Journal of Pharmaceutical Sciences 102 (5), pp. 1434-1446.

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Abstract

The aim of the present study was to quantitatively assess the relevance of transparency and refractive index (RI) on protein particle analysis by the light-based techniques light obscuration (LO) and Micro-Flow Imaging (MFI). A novel method for determining the RI of protein particles was developed and provided an RI of 1.41 for protein particles from two different proteins. An increased RI of the ...

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Item type:Article
Date:May 2013
Institutions:UNSPECIFIED
Identification Number:
ValueType
23463514PubMed ID
10.1002/jps.23479DOI
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Unknown
Created at the University of Regensburg:No
Item ID:29041
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