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[18F]-fluoro-ethyl-L-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma

Hutterer, Markus, Nowosielski, Martha, Putzer, Daniel, Jansen, Nathalie L., Seiz, Marcel, Schocke, Michael, McCoy, Mark, Göbel, Georg, la Fougère, Christian, Virgolini, Irene J, Trinka, Eugen, Jacobs, Andreas H. and Stockhammer, Günther (2013) [18F]-fluoro-ethyl-L-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma. Neuro-oncology 15 (3), pp. 341-351.

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Abstract

(18)F-FET PET has a high sensitivity for the detection of high-grade brain tumors. Its specificity, however, is limited by passive tracer influx through a disrupted blood-brain barrier and (18)F-FET uptake in nonneoplastic brain lesions. Gliomas show specific tracer uptake in the absence of CE on MRI, which most likely reflects biologically active tumor.


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Item type:Article
Date:March 2013
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
23788269PubMed ID
10.1093/neuonc/nos300DOI
Classification:
NotationType
AdolescentMESH
AdultMESH
AgedMESH
Aged, 80 and overMESH
Blood-Brain Barrier/radionuclide imagingMESH
Brain Neoplasms/radionuclide imagingMESH
FemaleMESH
Fluorodeoxyglucose F18/diagnostic useMESH
Follow-Up StudiesMESH
Glioma/radionuclide imagingMESH
HumansMESH
Image Processing, Computer-AssistedMESH
Magnetic Resonance ImagingMESH
MaleMESH
Middle AgedMESH
Neoplasm GradingMESH
Positron-Emission TomographyMESH
PrognosisMESH
Radiopharmaceuticals/diagnostic useMESH
Retrospective StudiesMESH
Sensitivity and SpecificityMESH
Tyrosine/diagnostic useMESH
Young AdultMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29108
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