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[18F]-fluoro-ethyl-L-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma

Hutterer, Markus ; Nowosielski, Martha ; Putzer, Daniel ; Jansen, Nathalie L. ; Seiz, Marcel ; Schocke, Michael ; McCoy, Mark ; Göbel, Georg ; la Fougère, Christian ; Virgolini, Irene J ; Trinka, Eugen ; Jacobs, Andreas H. ; Stockhammer, Günther



Abstract

(18)F-FET PET has a high sensitivity for the detection of high-grade brain tumors. Its specificity, however, is limited by passive tracer influx through a disrupted blood-brain barrier and (18)F-FET uptake in nonneoplastic brain lesions. Gliomas show specific tracer uptake in the absence of CE on MRI, which most likely reflects biologically active tumor.


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