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Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases

Spanberger, Thomas ; Berghoff, Anna S. ; Dinhof, Carina ; Ilhan-Mutlu, Aysegül ; Magerle, Manuel ; Hutterer, Markus ; Pichler, Josef ; Wöhrer, Adelheid ; Hackl, Monika ; Widhalm, Georg ; Hainfellner, Johannes A. ; Dieckmann, Karin ; Marosi, Christine ; Birner, Peter ; Prayer, Daniela ; Preusser, Matthias


To analyze the prognostic value of the extent of peritumoral brain edema in patients operated for single brain metastases (BM), we retrospectively evaluated pre-operative magnetic resonance images in a discovery cohort of 129 patients and a validation cohort of 118 patients, who underwent neurosurgical resection of a single BM in two different hospitals. We recorded clinical parameters and ...


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