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Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases

Spanberger, Thomas, Berghoff, Anna S., Dinhof, Carina, Ilhan-Mutlu, Aysegül, Magerle, Manuel, Hutterer, Markus, Pichler, Josef, Wöhrer, Adelheid, Hackl, Monika, Widhalm, Georg, Hainfellner, Johannes A., Dieckmann, Karin, Marosi, Christine, Birner, Peter, Prayer, Daniela and Preusser, Matthias (2013) Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases. Clinical & experimental metastasis 30 (4), pp. 357-368.

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Abstract

To analyze the prognostic value of the extent of peritumoral brain edema in patients operated for single brain metastases (BM), we retrospectively evaluated pre-operative magnetic resonance images in a discovery cohort of 129 patients and a validation cohort of 118 patients, who underwent neurosurgical resection of a single BM in two different hospitals. We recorded clinical parameters and ...

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Item type:Article
Date:April 2013
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
23076770PubMed ID
10.1007/s10585-012-9542-9DOI
Classification:
NotationType
AdultMESH
AgedMESH
Aged, 80 and overMESH
Austria/epidemiologyMESH
Brain Edema/mortalityMESH
Brain Neoplasms/secondaryMESH
FemaleMESH
Follow-Up StudiesMESH
HumansMESH
Hypoxia-Inducible Factor 1, alpha Subunit/metabolismMESH
Immunoenzyme TechniquesMESH
Magnetic Resonance ImagingMESH
MaleMESH
Middle AgedMESH
Neoplasms/pathologyMESH
Neovascularization, Pathologic/mortalityMESH
NeuroimagingMESH
PrognosisMESH
Retrospective StudiesMESH
Survival RateMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29109
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