Kern, K., Schebesch, Karl-Michael, Schlaier, J., Hansen, Ernil, Feigl, Guenther C., Brawanski, Alexander and Lange, M.
(2012)
Levetiracetam compared to phenytoin for the prevention of postoperative seizures after craniotomy for intracranial tumours in patients without epilepsy.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 19 (1), pp. 99-100.
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Abstract
Anticonvulsant drugs are frequently given after craniotomy. Phenytoin (PHT) is the most commonly used agent; levetiracetam (LEV) is a new anticonvulsant drug with fewer side effects. To compare the incidence of seizures in patients receiving either prophylactic PHT or LEV perioperatively, 971 patients undergoing a craniotomy were analysed retrospectively during a 2-year period. PHT was used ...
Abstract
Anticonvulsant drugs are frequently given after craniotomy. Phenytoin (PHT) is the most commonly used agent; levetiracetam (LEV) is a new anticonvulsant drug with fewer side effects. To compare the incidence of seizures in patients receiving either prophylactic PHT or LEV perioperatively, 971 patients undergoing a craniotomy were analysed retrospectively during a 2-year period. PHT was used routinely and LEV was administered when PHT was contraindicated. Seizures documented during the first 7 days after craniotomy were considered. A total of 235 patients were treated with an antiepileptic drug: 81 patients received LEV, and 154 patients, PHT. Two patients receiving LEV (2.5%) and seven receiving PHT (4.5%) had a seizure despite this treatment. No patient had a documented side effect or drug interaction. The data show that LEV may be an alternative option in patients with contraindications to PHT.
Export bibliographical data
| Item type: | Article |
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| Date: | 2012 |
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| Institutions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT) |
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| Identification Number: | | Value | Type |
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| 22133815 | PubMed ID | | 10.1016/j.jocn.2011.07.021 | DOI |
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| Classification: | | Notation | Type |
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| Adolescent | MESH | | Adult | MESH | | Aged | MESH | | Aged, 80 and over | MESH | | Brain Neoplasms/surgery | MESH | | Child | MESH | | Craniotomy/methods | MESH | | Female | MESH | | Humans | MESH | | Male | MESH | | Middle Aged | MESH | | Phenytoin/therapeutic use | MESH | | Piracetam/therapeutic use | MESH | | Postoperative Complications/prevention & control | MESH | | Retrospective Studies | MESH | | Seizures/prevention & control | MESH | | Young Adult | MESH |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine |
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| Status: | Published |
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| Refereed: | Yes, this version has been refereed |
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| Created at the University of Regensburg: | Unknown |
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| Item ID: | 29170 |
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