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Function of carbonic anhydrase IX in glioblastoma multiforme

Proescholdt, Martin A., Merrill, Marsha J., Stoerr, Eva-Maria, Lohmeier, Annette, Pohl, Fabian and Brawanski, Alexander (2012) Function of carbonic anhydrase IX in glioblastoma multiforme. Neuro-oncology 14 (11), pp. 1357-1366.

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Abstract

Carbonic anhydrase (CA) IX is over-expressed in glioblastoma; however, its functions in this context are unknown. Metabolically, glioblastomas are highly glycolytic, leading to a significant lactic acid load. Paradoxically, the intracellular pH is alkaline. We hypothesized that CAIX contributes to the extrusion of hydrogen ions into the extracellular space, thereby moderating intra- and ...

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Item type:Article
Date:2012
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
15342400PubMed ID
10.1093/neuonc/nos216DOI
Classification:
NotationType
Blotting, WesternMESH
Brain Neoplasms/mortalityMESH
Carbonic Anhydrase IV/metabolismMESH
Cell Adhesion/physiologyMESH
Cell Movement/physiologyMESH
FemaleMESH
Glioblastoma/mortalityMESH
HumansMESH
ImmunohistochemistryMESH
Kaplan-Meier EstimateMESH
MaleMESH
Middle AgedMESH
Neoplasm InvasivenessMESH
PrognosisMESH
RNA InterferenceMESH
Tumor Markers, Biological/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29172
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