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Function of carbonic anhydrase IX in glioblastoma multiforme

Proescholdt, Martin A. ; Merrill, Marsha J. ; Stoerr, Eva-Maria ; Lohmeier, Annette ; Pohl, Fabian ; Brawanski, Alexander



Abstract

Carbonic anhydrase (CA) IX is over-expressed in glioblastoma; however, its functions in this context are unknown. Metabolically, glioblastomas are highly glycolytic, leading to a significant lactic acid load. Paradoxically, the intracellular pH is alkaline. We hypothesized that CAIX contributes to the extrusion of hydrogen ions into the extracellular space, thereby moderating intra- and ...

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