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TGF-β2 signaling in high-grade gliomas

Hau, Peter ; Jachimczak, Piotr ; Schlaier, Jürgen ; Bogdahn, Ulrich



Abstract

High-grade gliomas are the most common primary tumors in the central nervous system (CNS) in adults. Despite efforts to improve treatment by combination therapies (neurosurgery, radio- and chemotherapy), high-grade glioma patients still have a grim prognosis, indicating an urgent need for new therapeutic approaches. The molecular processes of gliomagenesis are being unraveled, and novel targeted ...

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