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Unraveling the glioma epigenome: from molecular mechanisms to novel biomarkers and therapeutic targets

Malzkorn, Bastian ; Wolter, Marietta ; Riemenschneider, Markus J. ; Reifenberger, Guido



Abstract

Epigenetic regulation of gene expression by DNA methylation and histone modification is frequently altered in human cancers including gliomas, the most common primary brain tumors. In diffuse astrocytic and oligodendroglial gliomas, epigenetic changes often present as aberrant hypermethylation of 5'-cytosine-guanine (CpG)-rich regulatory sequences in a large variety of genes, a phenomenon ...

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