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Unraveling the glioma epigenome: from molecular mechanisms to novel biomarkers and therapeutic targets

Malzkorn, Bastian, Wolter, Marietta, Riemenschneider, Markus J. and Reifenberger, Guido (2011) Unraveling the glioma epigenome: from molecular mechanisms to novel biomarkers and therapeutic targets. Brain pathology 21 (6), pp. 619-632.

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Abstract

Epigenetic regulation of gene expression by DNA methylation and histone modification is frequently altered in human cancers including gliomas, the most common primary brain tumors. In diffuse astrocytic and oligodendroglial gliomas, epigenetic changes often present as aberrant hypermethylation of 5'-cytosine-guanine (CpG)-rich regulatory sequences in a large variety of genes, a phenomenon ...

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Item type:Article
Date:2011
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
21939466PubMed ID
10.1111/j.1750-3639.2011.00536.xDOI
Classification:
NotationType
AnimalsMESH
Brain Neoplasms/geneticsMESH
Epigenesis, Genetic/geneticsMESH
Glioma/geneticsMESH
HumansMESH
Tumor Markers, Biological/geneticsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29184
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