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Expression of carbonic anhydrase IX in craniopharyngiomas

Proescholdt, Martin A. ; Merrill, Marsha ; Stoerr, Eva-Maria ; Lohmeier, Annette ; Dietmaier, Wolfgang ; Brawanski, Alexander


Carbonic anhydrase IX, which is virtually absent in normal brain, is significantly upregulated in craniopharyngiomas and shows a significant association with cyst size. The mechanisms of regulation remain unknown, since neither hypoxia nor p53 appears to play a role. These results indicate that inhibition of CA IX may be a potential target for the adjuvant treatment in patients with cystic craniopharyngiomas.

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