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Expression of carbonic anhydrase IX in craniopharyngiomas

Proescholdt, Martin A., Merrill, Marsha, Stoerr, Eva-Maria, Lohmeier, Annette, Dietmaier, Wolfgang and Brawanski, Alexander (2011) Expression of carbonic anhydrase IX in craniopharyngiomas. Journal of neurosurgery 115 (4), pp. 796-801.

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Abstract

Carbonic anhydrase IX, which is virtually absent in normal brain, is significantly upregulated in craniopharyngiomas and shows a significant association with cyst size. The mechanisms of regulation remain unknown, since neither hypoxia nor p53 appears to play a role. These results indicate that inhibition of CA IX may be a potential target for the adjuvant treatment in patients with cystic craniopharyngiomas.


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Item type:Article
Date:2011
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
21761968PubMed ID
10.3171/2011.6.JNS1168DOI
Classification:
NotationType
AdolescentMESH
AdultMESH
AgedMESH
Antigens, Neoplasm/metabolismMESH
Carbonic Anhydrases/metabolismMESH
ChildMESH
Child, PreschoolMESH
Craniopharyngioma/metabolismMESH
FemaleMESH
HumansMESH
Hypoxia-Inducible Factor 1, alpha Subunit/metabolismMESH
MaleMESH
Middle AgedMESH
Pituitary Neoplasms/metabolismMESH
Tumor Markers, Biological/metabolismMESH
Vascular Endothelial Growth Factor A/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29185
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