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1H-nuclear magnetic resonance spectroscopy of glioblastoma cancer stem cells

Ramm, Paul ; Bettscheider, Marc ; Beier, Dagmar ; Kalbitzer, Hans Robert ; Kremer, Werner ; Bogdahn, Ulrich ; Hau, Peter ; Aigner, Ludwig ; Beier, Christoph P.



Abstract

The noninvasive tracking of glioblastoma cancer stem cells (CSCs) in vivo constitutes a prerequisite for the development of CSC-specific therapies. Therefore, as a pilot study to identify CSC biomarkers for clinical magnetic resonance spectroscopy, 10 CSC lines were investigated using high-resolution (1)H-nuclear magnetic resonance ((1)H-NMR) spectroscopy at 600 and 800 MHz (14.4 and 18.8 T) ...

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