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Transcranial electro-hyperthermia combined with alkylating chemotherapy in patients with relapsed high-grade gliomas: phase I clinical results

Wismeth, Caecilia ; Dudel, Christine ; Pascher, Christina ; Ramm, Paul ; Pietsch, Torsten ; Hirschmann, Birgit ; Reinert, Christiane ; Proescholdt, Martin A. ; Rümmele, Petra ; Schuierer, Gerhard ; Bogdahn, Ulrich ; Hau, Peter



Abstract

Non-invasive loco-regional electro-hyperthermia (EHT) plus alkylating chemotherapy is occasionally used as salvage treatment in the relapse of patients with high-grade gliomas. Experimental data and retrospective studies suggest potential effects. However, no prospective clinical results are available. We performed a single-center prospective non-controlled single-arm Phase I trial. Main ...

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