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Hypermethylation and transcriptional downregulation of the TIMP3 gene is associated with allelic loss on 22q12.3 and malignancy in meningiomas

Barski, Dimitri, Wolter, Marietta, Reifenberger, Guido and Riemenschneider, Markus J. (2010) Hypermethylation and transcriptional downregulation of the TIMP3 gene is associated with allelic loss on 22q12.3 and malignancy in meningiomas. Brain pathology 20 (3), pp. 623-631.

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Abstract

The gene for the tissue inhibitor of metalloproteinase 3 (TIMP3) on 22q12.3 had been reported to be inactivated by promoter methylation in various types of cancers, with controversial findings in meningiomas. We performed direct sodium bisulfite sequencing in a series of 50 meningiomas, including 27 benign meningiomas [World Health Organization (WHO) grade I], 11 atypical meningiomas (WHO grade ...

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Item type:Article
Date:2010
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
19922547PubMed ID
10.1111/j.1750-3639.2009.00340.xDOI
Classification:
NotationType
AgedMESH
Aged, 80 and overMESH
Cell Line, TumorMESH
Chromosomes, Human, Pair 22/geneticsMESH
DNA Methylation/geneticsMESH
Disease ProgressionMESH
Down-Regulation/geneticsMESH
HumansMESH
Loss of Heterozygosity/geneticsMESH
MaleMESH
Meningeal Neoplasms/metabolismMESH
Meningioma/metabolismMESH
Middle AgedMESH
RNA Interference/physiologyMESH
Tissue Inhibitor of Metalloproteinase-3/geneticsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29213
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