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Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma

Tepel, Martin, Roerig, Peter, Wolter, Marietta, Gutmann, David H, Perry, Arie, Reifenberger, Guido and Riemenschneider, Markus J. (2008) Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma. International journal of cancer. Journal international du cancer 123 (9), pp. 2080-2086.

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Abstract

The N-myc downstream-regulated gene 2 (NDRG2) at 14q11.2 has been reported to be downregulated in glioblastoma, and NDRG2 overexpression represses glioblastoma cell proliferation in vitro (Deng et al., Int J Cancer 2003;106;342-7). To further address the role of NDRG2 as a candidate tumor suppressor in human gliomas, we analyzed 67 astrocytic tumors (10 diffuse astrocytomas, 11 anaplastic ...

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Item type:Article
Date:2008
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
18709645PubMed ID
10.1002/ijc.23705DOI
Classification:
NotationType
Brain Neoplasms/mortalityMESH
Chromosomes, Human, Pair 14MESH
DNA MethylationMESH
Down-RegulationMESH
Gene Expression Regulation, NeoplasticMESH
Gene SilencingMESH
Genes, Tumor SuppressorMESH
Glioblastoma/mortalityMESH
HumansMESH
ImmunohistochemistryMESH
Promoter Regions, GeneticMESH
RNA, Messenger/analysisMESH
Tumor Suppressor Proteins/geneticsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29226
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