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Downregulation of RUNX3 and TES by hypermethylation in glioblastoma

Mueller, W. ; Nutt, C. L. ; Ehrich, M. ; Riemenschneider, Markus J. ; von Deimling, A. ; van den Boom, D. ; Louis, D. N.


Glioblastoma, the most aggressive and least treatable form of malignant glioma, is the most common human brain tumor. Although many regions of allelic loss occur in glioblastomas, relatively few tumor suppressor genes have been found mutated at such loci. To address the possibility that epigenetic alterations are an alternative means of glioblastoma gene inactivation, we coupled pharmacological ...


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