Go to content
UR Home

AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling

Riemenschneider, Markus J., Betensky, Rebecca A., Pasedag, Saskia M. and Louis, David N. (2006) AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer research 66 (11), pp. 5618-5623.

Full text not available from this repository.

at PubMed

at publisher (via DOI)


Abstract

Aberrant AKT (protein kinase B) signaling is common in many cancers, including glioblastoma. Current models suggest that AKT acts directly, or indirectly via the TSC complex, to activate the mammalian target of rapamycin (mTOR) as the main downstream mediator of AKT signaling. mTOR activation results in subsequent activation of S6K and STAT3, as well as suppression (i.e., phosphorylation) of ...

plus


Export bibliographical data



Item type:Article
Date:2006
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
16740698PubMed ID
10.1158/0008-5472.CAN-06-0364DOI
Classification:
NotationType
Cell Growth Processes/physiologyMESH
Enzyme ActivationMESH
Glioblastoma/pathologyMESH
HumansMESH
ImmunohistochemistryMESH
Proto-Oncogene Proteins c-akt/metabolismMESH
Ribosomal Protein S6 Kinases/metabolismMESH
Signal TransductionMESH
Tumor Suppressor Proteins/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29247
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons