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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Stupp, Roger ; Hegi, Monika E. ; Mason, Warren P. ; van den Bent, Martin J. ; Taphoorn, Martin J. B. ; Janzer, Robert C. ; Ludwin, Samuel K. ; Allgeier, Anouk ; Fisher, Barbara ; Belanger, Karl ; Hau, Peter ; Brandes, Alba A. ; Gijtenbeek, Johanna ; Marosi, Christine ; Vecht, Charles J. ; Mokhtari, Karima ; Wesseling, Pieter ; Villa, Salvador ; Eisenhauer, Elizabeth ; Gorlia, Thierry ; Weller, Michael ; Lacombe, Denis ; Cairncross, J. Gregory ; Mirimanoff, René-Olivier



Abstract

Background In 2004, a randomised phase III trial by the European Organisation for Research and Treatment of Cancer (EORTC) and National Cancer Institute of Canada Clinical Trials Group (NCIC) reported improved median and 2-year survival for patients with glioblastoma treated with concomitant and adjuvant temozolomide and radiotherapy. We report the final results with a median follow-up of more ...

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