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Developing an in situ nanosuspension: A novel approach towards the efficient administration of poorly soluble drugs at the anterior eye

Luschmann, Christoph ; Tessmar, Joerg ; Schoeberl, Simon ; Framme, Carsten ; Luschmann, Karl ; Goepferich, Achim


With about 50–60 million cases in the US alone, dry eye disease represents a severe health care problem. Cyclosporin A (CsA) would be a potent candidate for a causal therapy. However, CsA is not sufficiently water soluble to be administrated via simple eye drops. We developed an in situ nanosuspension (INS) as a novel approach towards the administration of CsA to the cornea. It precipitates upon ...


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