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Developing an in situ nanosuspension: A novel approach towards the efficient administration of poorly soluble drugs at the anterior eye

Luschmann, Christoph, Tessmar, Joerg, Schoeberl, Simon, Framme, Carsten, Luschmann, Karl and Goepferich, Achim (2013) Developing an in situ nanosuspension: A novel approach towards the efficient administration of poorly soluble drugs at the anterior eye. European Journal of Pharmaceutical Sciences 50 (3-4), pp. 385-392.

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Abstract

With about 50–60 million cases in the US alone, dry eye disease represents a severe health care problem. Cyclosporin A (CsA) would be a potent candidate for a causal therapy. However, CsA is not sufficiently water soluble to be administrated via simple eye drops. We developed an in situ nanosuspension (INS) as a novel approach towards the administration of CsA to the cornea. It precipitates upon ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ejps.2013.07.002DOI
Keywords:Cyclosporin A; Nanosuspension; Poly(ethylene glycol); Solutol; Precipitation; Anterior eye
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29278
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