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Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application

Pollinger, Klaus ; Hennig, Robert ; Ohlmann, Andreas ; Fuchshofer, R. ; Wenzel, Rebecca ; Breunig, Miriam


To date, diseases affecting vascular structures in the posterior eye are mostly treated by laser photocoagulation and multiple intraocular injections, procedures that destroy healthy tissue and can cause vision-threatening complications. To overcome these drawbacks, we investigate the feasibility of receptor-mediated nanoparticle targeting to capillary endothelial cells in the retina after i.v. ...


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