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Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application

Pollinger, Klaus ; Hennig, Robert ; Ohlmann, Andreas ; Fuchshofer, R. ; Wenzel, Rebecca ; Breunig, Miriam



Abstract

To date, diseases affecting vascular structures in the posterior eye are mostly treated by laser photocoagulation and multiple intraocular injections, procedures that destroy healthy tissue and can cause vision-threatening complications. To overcome these drawbacks, we investigate the feasibility of receptor-mediated nanoparticle targeting to capillary endothelial cells in the retina after i.v. ...

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