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Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application

Pollinger, Klaus, Hennig, Robert, Ohlmann, Andreas, Fuchshofer, R., Wenzel, Rebecca and Breunig, Miriam (2013) Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 25, pp. 6115-6120.

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Abstract

To date, diseases affecting vascular structures in the posterior eye are mostly treated by laser photocoagulation and multiple intraocular injections, procedures that destroy healthy tissue and can cause vision-threatening complications. To overcome these drawbacks, we investigate the feasibility of receptor-mediated nanoparticle targeting to capillary endothelial cells in the retina after i.v. ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1073/pnas.1220281110DOI
Keywords:age-related macular degeneration; diabetic retinopathy; choroid; neovascularization; ligand receptor interaction
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29285
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