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Self-​assembling colloidal system for the ocular administration of cyclosporine A

Luschmann, Christoph ; Tessmar, Joerg ; Schoeberl, Simon ; Strauss, O. ; Luschmann, Karl ; Goepferich, Achim


PURPOSE: In this study, we developed a self-assembling micellar system to deliver cyclosporine A (CsA) in an aqueous solution to the cornea. METHODS: Two nonionic surfactants of the poly(ethylene glycol)-fatty alcohol ether type (Sympatens AS and Sympatens ACS) were characterized in terms of micelle size, shape, and charge, and their encapsulation efficiency for CsA. In an in situ single dose ...


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